Data science for buildings, a multi-scale approach bridging occupants to smart-city energy planning

In a context of global carbon emission reduction goals, buildings have been identified to detain valuable energy-saving abilities. With the exponential increase of smart, connected building automation systems, massive amounts of data are now accessible for analysis. These coupled with powerful data science methods and machine learning algorithms present a unique opportunity to identify untapped energy-saving potentials from field information, and effectively turn buildings into active assets of the built energy infrastructure.However, the diversity of building occupants, infrastructures, and the disparities in collected information has produced disjointed scales of analytics that make it tedious for approaches to scale and generalize over the building stock.This coupled with the lack of standards in the sector has hindered the broader adoption of data science practices in the field, and engendered the following questioning:How can data science facilitate the scaling of approaches and bridge disconnected spatiotemporal scales of the built environment to deliver enhanced energy-saving strategies?This thesis focuses on addressing this interrogation by investigating data-driven, scalable, interpretable, and multi-scale approaches across varying types of analytical classes. The work particularly explores descriptive, predictive, and prescriptive analytics to connect occupants, buildings, and urban energy planning together for improved energy performances.First, a novel multi-dimensional data-mining framework is developed, producing distinct dimensional outlines supporting systematic methodological approaches and refined knowledge discovery. Second, an automated building heat dynamics identification method is put forward, supporting large-scale thermal performance examination of buildings in a non-intrusive manner. The method produced 64\% of good quality model fits, against 14\% close, and 22\% poor ones out of 225 Dutch residential buildings. %, which were open-sourced in the interest of developing benchmarks. Third, a pioneering hierarchical forecasting method was designed, bridging individual and aggregated building load predictions in a coherent, data-efficient fashion. The approach was evaluated over hierarchies of 37, 140, and 383 nodal elements and showcased improved accuracy and coherency performances against disjointed prediction systems.Finally, building occupants and urban energy planning strategies are investigated under the prism of uncertainty. In a neighborhood of 41 Dutch residential buildings, occupants were determined to significantly impact optimal energy community designs in the context of weather and economic uncertainties.Overall, the thesis demonstrated the added value of multi-scale approaches in all analytical classes while fostering best data-science practices in the sector from benchmarks and open-source implementations

Hierarchical learning, forecasting coherent spatio-temporal individual and aggregated building loads

Optimal decision-making compels us to anticipate the future at different horizons. However, in many domains connecting together predictions from multiple time horizons and abstractions levels across their organization becomes all the more important, else decision-makers would be planning using separate and possibly conflicting views of the future. This notably applies to smart grid operation. To optimally manage energy flows in such systems, accurate and coherent predictions must be made across varying aggregation levels and horizons. With this work, we propose a novel multi-dimensional hierarchical forecasting method built upon structurally-informed machine-learning regressors and established hierarchical reconciliation taxonomy. A generic formulation of multi-dimensional hierarchies, reconciling spatial and temporal hierarchies under a common frame is initially defined. Next, a coherency-informed hierarchical learner is developed built upon a custom loss function leveraging optimal reconciliation methods. Coherency of the produced hierarchical forecasts is then secured using similar reconciliation technics. The outcome is a unified and coherent forecast across all examined dimensions. The method is evaluated on two different case studies to predict building electrical loads across spatial, temporal, and spatio-temporal hierarchies. Although the regressor natively profits from computationally efficient learning, results displayed disparate performances, demonstrating the value of hierarchical-coherent learning in only one setting. Yet, supported by a comprehensive result analysis, existing obstacles were clearly delineated, presenting distinct pathways for future work. Overall, the paper expands and unites traditionally disjointed hierarchical forecasting methods providing a fertile route toward a novel generation of forecasting regressors

Onsite evaluation of building airtightness durability: Long-term and mid-term field measurement study of 61 French low energy single family dwellings

International audienceThe increasing weight of building leakages energy impact on the overall energy performance of low-energy buildings led to a better understanding of the actual airtightness performance of buildings. However, low expertise is available today on the durability of airtightness products in mid-and long-term scales. The French ongoing research project "Durabilit'air" (2016-2019) aims at improving our knowledge on the variation of buildings airtightness through onsite measurement and accelerated ageing in laboratory controlled conditions. This paper is issued from the second task of the "Durabilit'air" project. This task deals with the quantification and qualification of the durability of building airtightness of single detached houses. It is done through field measurement at mid-term (MT) and long-term (LT) scales. This paper first presents the field measurement protocol. For the MT campaign, a sample of 30 new single-detached dwellings has been selected nationwide. During the study, the airtightness of each building is to be measured once per year over a 3-year period. A part of this sample is to be also measured twice per year in order to investigate the impact of seasonal variations. The LT campaign is to be carried out with a second sample of 31 existing single-detached dwellings constructed during the last 10 years. The airtightness of each dwelling is to be measured once. A specific measurement protocol was defined after a detailed literature review. The protocol is mainly based on the standard ISO 9972 for the measurement method with additional requirements for the measurement conditions (same tester, same calibrated measurement device, same building preparation, same pressure difference sequences, same season…). It also includes a detailed qualitative leakage detection and questionnaire for occupants. The main challenge is to understand the variations of the airtightness and to identify whether it is related to the products/assembly ageing, the maintenance conditions or other factors such as the occupants' behaviour. Secondly, this paper presents the 61 dwelling samples construction characteristics. All dwellings were tested upon completion. The air flow rates at 4 Pa per envelope area excluding lower floor of both samples show the same mean value around 0.3 m 3 .h-1 .m-2 (n50 of 1.4 h-1), with larger variations among the LT sample. Finally, we discuss first measurement results. Regarding MT sample, results after 1-2 years show a slight increase of airflow rate at 50 PA (q50) with a median value of +6%. However, with exposed timber framing, q50 has increased by more than 100%. Regarding LT campaign, measurements results after 3-10 years show a more important increase of q50 with a median value of 28%. The measurement campaigns and data analysis will continue over 2018 to complete the work in order to better understand the in situ variations of the buildings' envelope airtightness. KEYWORDS Airtightness durability, field measurements, building envelope, low-energy dwelling 1 INTRODUCTION The increasing weight of building leakages energy impact on the overall performance of low-energy buildings led to a better understanding and characterization of the actual airtightness performance of buildings. Several European countries have already included in their EP-regulation mandatory requirements regarding the building airtightness. This is the case in France, where the EP-regulation requires a limit airtightness level for residential buildings that must be justified by measurement. However, low expertise is available today on the durability of building airtightness and its evolution in mid-and long-term scales. The French ongoing research project "Durabilit'air" is conducted since 2016 for a 42-month period, in order to improve our knowledge on the variation of buildings airtightness through onsite measurement campaigns and accelerated ageing in laboratory controlled conditions. As part of this project, a comprehensive literature review about building airtightness durability was realized by (Leprince et al., 2017). This review showed an important evolution over time of the air permeability in real buildings, with an increase of more than twice in some cases. The air permeability seems to increase in the 3 first years and then stabilise. This paper is issued from the second task of the "Durabilit'air" project. This task deals with the quantification and qualification of the durability of building airtightness of single detached houses. It is done through field measurement at mid-term (MT) and long-term (LT) scales. This paper presents the first results of both MT and LT measurements

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20 : G protein- coupled receptors

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14748. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.Peer reviewe

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate